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SRI 37892
CAS No. 1030769-75-5
SRI 37892( SRI37892 | SRI-37892 )
Catalog No. M10150 CAS No. 1030769-75-5
SRI 37892 (SRI37892) is a novel potent, small molecule Frizzled 7 (Fzd 7) inhibitor with IC50 of 0.66 uM in Wnt/β-catenin assay.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 10MG | 1161 | Get Quote |
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| 25MG | 1755 | Get Quote |
|
| 50MG | 2358 | Get Quote |
|
| 100MG | 3177 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameSRI 37892
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NoteResearch use only, not for human use.
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Brief DescriptionSRI 37892 (SRI37892) is a novel potent, small molecule Frizzled 7 (Fzd 7) inhibitor with IC50 of 0.66 uM in Wnt/β-catenin assay.
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DescriptionSRI 37892 (SRI37892) is a novel potent, small molecule Frizzled 7 (Fzd 7) inhibitor with IC50 of 0.66 uM in Wnt/β-catenin assay; also displays potent activity against Wnt/β-catenin signaling in LRP6-expressing HEK293 cells with IC50 of 0.78 uM, demonstrates potent activity against breast cancer HS578T and BT549 cell proliferation with IC50 of 2.2 and 1.9 uM, respectively; targets Fzd7 transmembrane domain (TMD) and bolcks Wnt/Fzd7 signaling.
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In Vitro——
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In Vivo——
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SynonymsSRI37892 | SRI-37892
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PathwayWnt/Notch/Hedgehog
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TargetFrizzled
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RecptorFrizzled
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Research Area——
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Indication——
Chemical Information
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CAS Number1030769-75-5
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Formula Weight465.531
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Molecular FormulaC26H19N5O2S
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(NC1=NC(C2=CC3=C(NC(CC3)=O)C=C2)=CS1)C4=CC=C(N5C=NC6=CC=CC=C56)C=C4
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Chemical Name4-(1H-benzo[d]imidazol-1-yl)-N-(4-(2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)thiazol-2-yl)benzamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zhang W, et al. Oncotarget. 2017 Sep 6;8(53):91459-91470.
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